Julia Community 🟣: johnswift

Peptidomimetic Drug Screening Service for Neurological Diseases

johnswift — Sat, 10 Nov 2018 09:10:06 +0000

Overview of Neurological Diseases
Structural, biochemical, or electrical abnormalities of the brain, spinal cord, or other nerves can lead to a range of neurological symptoms, including paralysis, muscle weakness, poor coordination, sensory loss, seizures, psychosis, pain, and altered levels of consciousness. At present, more than 600 neurological diseases have been found in the world. Neurological diseases and their sequelae affect as many as 1 billion people in the world.

Advantages of Peptidomimetic Drugs
The specific causes of nervous system problems vary, but may be due to genetics, congenital anomalies, infections, etc. Because the pathogenesis is ambiguous, it is difficult to truly treat effectively, and the medical community is working to find new drugs for the treatment of nervous system diseases. Peptide-mimetic drugs of biologically active proteins have attracted widespread attention due to their good efficacy, low molecular weight, low side effects, and better membrane penetration.

NACOFUL TITANIUM DIOXIDE

johnswift — Sat, 10 Nov 2018 09:06:17 +0000

Nacoful titanium dioxide is a natural white inorganic substance that is non-toxic and odorless, and is therefore widely used in the pharmaceutical, food and cosmetic industries. The pigment is a common colorant used in the food processing industry to improve the appearance of food products by increasing their gloss and whiteness. Since titanium dioxide is non-toxic, it is also being used more frequently in cosmetics. To permanently tint the spice powder white, only 5%–8% of titanium dioxide must be applied. This also increases the spice's slipperiness, adherence, and covering power.

As a food coloring and whitening agent, food-grade titanium dioxide is frequently used in foods that require whitening, such as candy coating, chilled fruit, jelly, chewing gum, preserves, jam and mayonnaise. Additionally, the pigment is used in cosmetic products like foundation, powder, sunscreen, etc.

Titanium dioxide is a very common food additive in life. In general, trace amounts of titanium dioxide are harmless to the human body and have no effect on the body. Titanium dioxide is an acidic amphoteric oxide with very stable chemical properties. It hardly reacts with other elements and compounds at room temperature, is insoluble in water, fats, dilute acids, inorganic acids and bases, and is soluble only in hydrofluoric acid.

Association Study of Age Acceleration and Cancer Risk

johnswift — Sat, 10 Nov 2018 09:04:34 +0000

Methylation-Based Biological Age and Cancer Risk
Changes in DNA methylation levels with age, and it has been widely studied as a well-known biomarker of aging. A number of DNA methylation age clocks have appeared and been used, and when the age predicted by the methylation clock is greater than the actual age, it is considered to have "age acceleration", which is also called the biological measure of aging.

Research suggests a correlation between aging and cancer as well. Predicted ages obtained by DNA methylation analysis are greater than actual ages, indicating age acceleration, and these phenomena may also be strongly associated with cancer risk. By analyzing the age acceleration of DNA methylation to discover their association with increased cancer risk or shorter survival, it could help to understand specific relationship between the aging process and cancer development, developing DNA methylation as a tool for predicting cancer risk.

Application Areas

Gastric cancer research
Lung cancer research
Kidney cancer research
Breast cancer research
Lymphoma research
Rectal cancer research